Statistical optimization of tretinoin-loaded penetration-enhancer vesicles (PEV) for topical delivery
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چکیده
منابع مشابه
Penetration enhancer-containing vesicles (PEVs) as carriers for cutaneous delivery of minoxidil.
The aim of this work was to evaluate the ability of a few different penetration enhancers to produce elastic vesicles with soy lecithin and the influence of the obtained vesicles on in vitro (trans)dermal delivery of minoxidil. To this purpose, so-called Penetration Enhancer-containing Vesicles (PEVs) were prepared as dehydrated-rehydrated vesicles by using soy lecithin and different amounts of...
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Many properties of chemicals depend on their stereochemistry. Among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. We have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. As, depending on their lipophilicity, penetration enhancers can change ...
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Many properties of chemicals depend on their stereochemistry. Among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. We have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. As, depending on their lipophilicity, penetration enhancers can change ...
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Dear Friends, We all are well known with a fact of benefits of novel topical drug delivery systems, namely avoidance of hepatic first-pass metabolism, thus improving drug bioavailability, decreasing dosing frequency, and improving patient compliance. Regardless of the enormous investigations in topical and transdermal drug delivery systems, still stratum corneum is known as a major obstacle whi...
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ژورنال
عنوان ژورنال: DARU Journal of Pharmaceutical Sciences
سال: 2016
ISSN: 2008-2231
DOI: 10.1186/s40199-016-0142-0